DNA replication: telling time with microarrays

被引:0
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作者
Heather J McCune
Anne D Donaldson
机构
[1] University of Washington,Department of Genome Sciences
[2] School of Life Sciences,Cancer Research UK Chromosome Replication Group, Division of Gene Regulation and Expression
[3] University of Dundee,undefined
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关键词
High Eukaryote; Replication Origin; Transcriptional Silence; Replication Timing; Nuclear Periphery;
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摘要
A long-standing hypothesis about eukaryotic DNA replication is that the late-replicating regions are transcriptionally inert and that repressing transcription delays replication initiation. But do contrasting results from yeast and a recent study in Drosophila imply that replication timing and transcriptional activity are differentially regulated in yeast and higher eukaryotes?
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