MicroRNA Biogenesis Pathway Gene Polymorphisms Are Associated with Breast Cancer Risk

被引：0

作者：

M. A. Bermisheva

Z. R. Takhirova

I. R. Gilyazova

E. K. Khusnutdinova

机构：

[1] Russian Academy of Sciences,Institute of Biochemistry and Genetics, Ufa Science Center

[2] Bashkir State University,Department of Genetics and Fundamental Medicine

来源：

Russian Journal of Genetics | 2018年 / 54卷

关键词：

breast cancer; miRNA; association; SNP; disease risk;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

MicroRNAs (miRNAs) play an important role as epigenetic regulators in cancer initiation and progression. One of the mechanisms of miRNA dysregulation is altered functioning of proteins involved in miRNA processing machinery. It has been suggested that single nucleotide polymorphisms (SNPs) within miRNA gene regions, miRNA target genes, and miRNA machinery genes may affect the miRNAs regulation. We selected 25 SNPs in the key genes of miRNA biosynthesis, including DROSHA/RNASEN, DGCR8, DICER1, XPO5, RAN, PIWIL1/HIWI, AGO1/EIF2C1, AGO2, GEMIN4, GEMIN3/DDX20, and DDX5, and investigated the association between these SNPs and the risk of breast cancer. The total number of breast cancer cases and cancer-free controls enrolled in the investigation were 778 (417 breast cancer patients and 361 healthy women). We found that rs11060845 and rs10773771 in the PIWIL1 gene, rs3809142/RAN, rs10719/DROSHA, rs1640299/DGCR8, rs563002/DDX20, rs595055/AGO1, and rs2740348/GEMIN4 were associated with breast cancer risk in Russians.

引用

页码：568 / 575

页数：7

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