With the classification data covering American land-use/land-cover (LUCC) with 30 m resolution from the project of National Land Cover Data (NLCD), we normalized them and made their resolution changed into 1 km × 1 km, created the data of American land-use grade and analyzed the spatial distribution and features of American LUCC as well as the influence of population and altitude on the land-use grade in light of methods of sampling analysis and correlation study. Based on the analysis, we concluded that forestry and grassland, accounting for 71.24% of the whole country, has taken the main part of American land cover, and besides, construction and arable land has occupied 19.22% of the total land, the rest of land cover types, including water area, wetland and underdeveloped land, is 9.54% of the country’s total. The developing potential of American land resources is enormous with less destroyed and disturbed ecological environment. Although, in some sense, the population and altitude influence the spatial variation of American land-use grade respectively, the influence of spatial variation of altitude and population density on that of land-use grade is not significant.