Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii

被引：0

作者：

Kisaburo Nagamune

Leslie M. Hicks

Blima Fux

Fabien Brossier

Eduardo N. Chini

L. David Sibley

机构：

[1] Washington University School of Medicine,Department of Molecular Microbiology

[2] 660 S. Euclid Avenue,Department of Anesthesiology

[3] St Louis,undefined

[4] Missouri 63110,undefined

[5] USA,undefined

[6] Donald Danforth Plant Science Center,undefined

[7] 975 N. Warson Road,undefined

[8] St Louis,undefined

[9] Missouri 63132,undefined

[10] USA ,undefined

[11] Mayo Clinic and Foundation,undefined

[12] Rochester,undefined

[13] Minnesota 55905,undefined

[14] USA,undefined

[15] Present addresses: Department of Immunoregulation,undefined

[16] Research Institute for Microbial Diseases,undefined

[17] Osaka University,undefined

[18] Osaka 565-0871,undefined

[19] Japan (K.N.); Linstitut National de la Researche Agronomique,undefined

[20] Centre de Recherche de Tours,undefined

[21] 37380 Nouzilly,undefined

[22] France (F.B.).,undefined

来源：

Nature | 2008年 / 451卷

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摘要：

Calcium signalling plays an important role in determining the virulence of the human pathogen Toxoplasma gondii, an apicomplexan protozoon. A study of the mechanisms involved has uncovered a surprising agent for this signalling: the plant hormone abscisic acid. Comparative genomics reveals that the pathway for synthesis of the plant hormone was acquired by endosymbiosis. This pathway controls a crucial developmental switch between lytic growth and dormancy, which is a key component of pathogenesis. The plant-like nature of this pathway may be exploited to develop new therapeutics as shown by the ability of a specific inhibitor of abscisic acid biosynthesis to protect mice from lethal infection.

引用

页码：207 / 210

页数：3

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