Human lactoferrin but not lysozyme neutralizes HSV-1 and inhibits HSV-1 replication and cell-to-cell spread

被引：0

作者：

Hannamari Välimaa

Jorma Tenovuo

Matti Waris

Veijo Hukkanen

机构：

[1] University of Turku,Institute of Dentistry

[2] University of Turku,Department of Virology

[3] Haartman Institute,Department of Virology

[4] University of Helsinki,Department of Oral Diseases

[5] Helsinki University Central Hospital Laboratory,Department of Microbiology

[6] Turku University Central Hospital,undefined

[7] University of Oulu,undefined

来源：

Virology Journal | / 6卷

关键词：

Human Lactoferrin; Cellular Counterpart; Cell Surface GAGs; Primary Herpes Simplex Virus Type;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The frequent oral shedding of herpes simplex virus type 1 (HSV-1) in the absence of clinical disease suggests that symptomatic HSV-1 recurrences may be inhibited by the mucosal environment. Indeed, saliva has been shown to contain substances with anti-HSV activity. In the current study, we investigated the anti-HSV-1 activity of human lactoferrin (hLf) and lysozyme (hLz), two highly cationic polypeptides of the mucosal innate defence system.

引用

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