Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro

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作者：
Jackelyn Murray
Robert J. Hogan
David E. Martin
Kathy Blahunka
Fred D. Sancilio
Rajiv Balyan
Mark Lovern
Richard Still
Ralph A. Tripp
机构：
[1] University of Georgia,Department of Infectious Diseases
[2] TrippBio,Department of Chemistry and Biochemistry
[3] Inc.,undefined
[4] Certara,undefined
[5] Florida Atlantic University,undefined
来源：
Scientific Reports | / 11卷
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摘要：
Effective vaccines are slowing the COVID-19 pandemic, but SARS-CoV-2 will likely remain an issue in the future making it important to have therapeutics to treat patients. There are few options for treating patients with COVID-19. We show probenecid potently blocks SARS-CoV-2 replication in mammalian cells and virus replication in a hamster model. Furthermore, we demonstrate that plasma concentrations up to 50-fold higher than the protein binding adjusted IC90 value are achievable for 24 h following a single oral dose. These data support the potential clinical utility of probenecid to control SARS-CoV-2 infection in humans.
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