Central administration of alloxan impairs glucose tolerance in rats

被引：0
|
作者：
M. Salkovic-Petrisic
Z. Lackovic
S. Hoyer
P. Riederer
机构：
[1] School of Medicine and Croatian Institute for Brain Research,Department of Pharmacology
[2] University of Zagreb,Department of Pathology
[3] University of Heidelberg,Department of Clinical Neurochemistry and NPF Center of Excellence Laboratories
[4] Clinic of Psychiatry and Psychotherapy,undefined
[5] University of Würzburg,undefined
来源：
Journal of Neural Transmission | 2005年 / 112卷
关键词：
Keywords: Alloxan, intracerebroventricular, glucose, insulin.;
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摘要：
By means of oral glucose tolerance test (OGTT), we investigated glucose tolerance in rats pre-treated with intracerebroventricular and subcutaneous non-diabetogenic dose of betacytotoxic drug alloxan 7 days before OGTT. Being normoglycemic and normoinsulinemic pre-OGTT, at 30 minutes post-OGTT, alloxan intracerebroventricularly-treated rats had a lower glucose and a higher insulin plasma levels in comparison with controls or alloxan subcutaneously treated animals. Centrally administered alloxan seems to have brain related effect on the regulation of peripheral glucose tolerance and insulin secretion.
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页码：1391 / 1395
页数：4
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