A neural basis for melanocortin-4 receptor–regulated appetite

被引：0

作者：

Alastair S Garfield

Chia Li

Joseph C Madara

Bhavik P Shah

Emily Webber

Jennifer S Steger

John N Campbell

Oksana Gavrilova

Charlotte E Lee

David P Olson

Joel K Elmquist

Bakhos A Tannous

Michael J Krashes

Bradford B Lowell

机构：

[1] Diabetes and Metabolism,Division of Endocrinology, Department of Medicine

[2] Beth Israel Deaconess Medical Center,Division of Hypothalamic Research, Department of Internal Medicine

[3] Harvard Medical School,Department of Neurology

[4] Centre for Integrative Physiology,undefined

[5] Hugh Robson Building,undefined

[6] University of Edinburgh,undefined

[7] Diabetes,undefined

[8] Endocrinology and Obesity Branch,undefined

[9] National Institute of Diabetes and Digestive and Kidney Diseases,undefined

[10] National Institutes of Health,undefined

[11] National Institute on Drug Abuse,undefined

[12] National Institutes of Health,undefined

[13] Mouse Metabolism Core,undefined

[14] National Institute of Diabetes and Digestive and Kidney Diseases,undefined

[15] National Institutes of Health,undefined

[16] The University of Texas Southwestern Medical Center at Dallas,undefined

[17] Massachusetts General Hospital,undefined

[18] Harvard Medical School,undefined

[19] Program in Neuroscience,undefined

[20] Harvard Medical School,undefined

[21] Present addresses: Cardiovascular and Metabolic Diseases,undefined

[22] Pfizer,undefined

[23] Cambridge,undefined

[24] Massachusetts,undefined

[25] USA (B.P.S.),undefined

[26] and Division of Pediatric Endocrinology,undefined

[27] Department of Pediatrics,undefined

[28] University of Michigan,undefined

[29] Ann Arbor,undefined

[30] Michigan,undefined

[31] USA (D.P.O.).,undefined

来源：

Nature Neuroscience | 2015年 / 18卷

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学科分类号：

摘要：

Melanocortin 4 receptors (MC4Rs) are critical to the promotion of homeostatic satiety. The authors established paraventricular hypothalamus (PVH) MC4R-expressing neurons as a functional target for orexigenic arcuate nucleus agouti-related peptide–expressing neurons and identify an explicit PVH MC4R-expressing neuron to lateral parabrachial nucleus satiety-promoting circuit, the activation of which encodes positive valence in calorically depleted mice.

引用

页码：863 / 871

页数：8

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