Changes in insulin receptor signaling underlie neoadjuvant metformin administration in breast cancer: a prospective window of opportunity neoadjuvant study

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作者
Ryan JO Dowling
Saroj Niraula
Martin C Chang
Susan J Done
Marguerite Ennis
David R McCready
Wey L Leong
Jaime M Escallon
Michael Reedijk
Pamela J Goodwin
Vuk Stambolic
机构
[1] University Health Network,Princess Margaret Cancer Centre
[2] CancerCare Manitoba and University of Manitoba,Department of Medical Oncology and Hematology
[3] Mount Sinai Hospital,Department of Laboratory Medicine and Pathology
[4] University of Toronto,Department of Laboratory Medicine and Pathobiology
[5] University Health Network,Campbell Family Institute for Breast Cancer Research and Laboratory Medicine Program
[6] Applied statistician,Department of Surgery
[7] Mount Sinai Hospital,Department of Surgical Oncology
[8] University of Toronto,Campbell Family Institute for Breast Cancer Research
[9] University Health Network,Division of Medical Oncology and Hematology, Department of Medicine, Mount Sinai Hospital, and Princess Margaret Cancer Centre
[10] University of Toronto,Department of Medical Biophysics
[11] Princess Margaret Cancer Centre,undefined
[12] University of Toronto,undefined
[13] University of Toronto,undefined
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关键词
Metformin; Insulin Receptor; AMPK Activation; Metformin Treatment; AMPK Phosphorylation;
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