Direct pro-angiogenic and indirect pro-metastatic properties of VEGF/VEGF receptors

被引：0
|
作者：
K. T. Lim
S. H. Teh
A. D. K. Hill
L. Young
E. McDermott
N. O’Higgins
机构：
[1] Mayo Clinic,Department of Surgery
[2] St Vincent’s University Hospital,undefined
来源：
Irish Journal of Medical Science | 2002年 / 171卷 / Suppl 2期
关键词：
D O I：
10.1007/BF03170114
中图分类号：
学科分类号：
摘要：
Our data demonstrate that EC promotes the metastatic potential of cancer cells by enhancing their migratory capability, which is partly due to EC uPA secretion. Two established VEGF receptors; Flt-1 and KDR signal different VEGF-mediated pro-neoplastic activities. Simultaneous blocking of both VEGF receptors allowed VEGF to continue exerting its pro-angiogenic effect. This suggests the possible activation of yet another VEGF receptor undiscovered under these conditions.
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