Singlet oxygen generation by sonication using a water-soluble fullerene (C60) complex: a potential application for sonodynamic therapy

被引：0
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作者：
Thi Lien Nguyen
Risa Katayama
Chie Kojima
Akikazu Matsumoto
Kazuhiko Ishihara
Shin-ichi Yusa
机构：
[1] University of Hyogo,Department of Applied Chemistry, Graduate School of Engineering
[2] Osaka Prefecture University,Department of Applied Chemistry, Graduate School of Engineering
[3] The University of Tokyo,Department of Materials Engineering, School of Engineering
来源：
Polymer Journal | 2020年 / 52卷
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摘要：
The generation of singlet oxygen (1O2) by sonicating a water-soluble complex of fullerene/poly(2-methacryloyloxyethyl phosphorylcholine) (C60/PMPC) was investigated for sonodynamic therapy (SDT). The effect of sonication time and the solubilized concentration of water-soluble fullerene C60 on the amount of generated 1O2 was studied. Singlet oxygen sensor green was used to confirm the generation of 1O2. 1O2 was generated from C60/PMPC under ultrasonic irradiation, and the amount of 1O2 increased with increasing solubilized C60 concentration and irradiation time. In cell viability tests, after 3 h of incubation, the cell viabilities were 10 and 84% in the presence of C60/PMPC with and without sonication, respectively. This result suggests that C60/PMPC shows a sonodynamic effect, which demonstrates its potential application in SDT.
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页码：1387 / 1394
页数：7
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