Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose

被引：0
|
作者：
Tiago B Rodrigues
Eva M Serrao
Brett W C Kennedy
De-En Hu
Mikko I Kettunen
Kevin M Brindle
机构：
[1] Cancer Research UK Cambridge Institute,Department of Biochemistry
[2] University of Cambridge,undefined
[3] University of Cambridge,undefined
来源：
Nature Medicine | 2014年 / 20卷
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摘要：
One of the most likely substrates for metabolic imaging of response to treatment in cancer is glucose, but until now, using hyperpolarized 13C-labelled glucose has been problematic because of the short lifetime of the hyperpolarization in this molecule. Using [U-13C, U-2H]glucose, Tiago Rodrigues et al. now show that they are able to image its glycolytic conversion to lactate in two mouse tumor models in vivo, and that in one model, flux is markedly reduced after treatment with the chemotherapeutic drug etoposide.
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页码：93 / 97
页数：4
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