Occlusive Properties of Monolayer Patches: In Vitro and in Vivo Evaluation

被引：0
|
作者：
Antonella Casiraghi
Paola Minghetti
Francesco Cilurzo
Luisa Montanari
Aarti Naik
机构：
[1] Istituto di Chimica Farmaceutica e Tossicologica,
[2] Center Interuniversitaire de Recherche et d'Enseignement,undefined
来源：
Pharmaceutical Research | 2002年 / 19卷
关键词：
transdermal patches; water vapour permeability; transepidermal water loss; ATR- FTIR spectroscopy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. Patches can cause a different grade of skin occlusion, depending on matrix composition and thickness, backing layer material. The aim of this work was to verify if in vitro water vapour permeability (WVP) values are predictive of transepidermal water loss (TEWL) and Fourier-transform infrared (FTIR) spectroscopy values measured in vivo after 24 h of methacrylic or acrylic monolayer patches application. The correlation between both in vivo methods has been evaluated.
引用
收藏
页码：423 / 426
页数：3
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