Frequency of Dendritic Cells and Their Expression of Costimulatory Molecules in Children with Autism Spectrum Disorders

被引：0
|
作者：
Khaled Saad
Asmaa M. Zahran
Khalid I. Elsayh
Ahmed A. Abdel-Rahman
Abdulrahman A. Al-Atram
Almontaser Hussein
Yasmin G. El-Gendy
机构：
[1] Assiut University,Pediatric Department, Faculty of Medicine
[2] Assiut University,Clinical Pathology Department, South Egypt Cancer Institute
[3] Assiut University,Department of Neuropsychiatry, Faculty of Medicine
[4] Almajmaah University,Department of Psychiatry, College of Medicine
[5] Ain Shams University,Pediatric Department, Faculty of Medicine
来源：
Journal of Autism and Developmental Disorders | 2017年 / 47卷
关键词：
Autism spectrum disorders; Dendritic cells; Innate immunity; Children;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The aim of our study was to evaluate the frequencies of myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs) in children with ASD. Subjects were 32 children with ASD and 30 healthy children as controls. The numbers of mDCs and pDCs and the expression of CD86 and CD80 on the entire DCs were detected by flow cytometry. ASD children had significantly higher percentages of mDCs and pDCs when compared to controls. We found significant inverse relationships between serum 25-hydroxyvitamin D levels and the frequencies of mDCs and pDCs in autistic children. Our data suggested that DCs could play a role in the clinical course of ASD. The relationship of DCs to immune disorders in ASD remains to be determined.
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页码：2671 / 2678
页数：7
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