Start of oral morphine to cancer patients: effective serum morphine concentrations and contribution from morphine-6-glucuronide to the analgesia produced by morphine

被引:0
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作者
P. Klepstad
S. Kaasa
P. C. Borchgrevink
机构
[1] Department of Anaesthesiology,
[2] University Hospital of Trondheim,undefined
[3] Norwegian University of Science and Technology,undefined
[4] Trondheim N-7006,undefined
[5] Norway e-mail: pklepsta@online.no Tel.: +47-738 68108; Fax: +47-738 68117,undefined
[6] Unit for Applied Clinical Research,undefined
[7] Norwegian University of Science and Technology,undefined
[8] Trondheim,undefined
[9] Norway,undefined
关键词
Key words Pain; Cancer; Morphine metabolites;
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学科分类号
摘要
Objective: To investigate the serum concentrations of morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) and the relationships between serum concentrations and clinical effects associated with start of morphine treatment in cancer patients.
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页码:713 / 719
页数:6
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