Nanoarchitectonics of Hydroxyapatite/Molybdenum Trioxide/Graphene Oxide Composite for Efficient Antibacterial Activity

Nanocomposites based on hydroxyapatite (HAP), including MoO3, HAP/MoO3, HAP/GO and HAP/MoO3/GO have been studied to be suggested for biological usage. The different compositions were investigated using FTIR, XRD, EDS, and XPS analysis. The tight relation between morphological features and composites' chemical ingredients was also studied. According to TEM micrographs, it was mentioned that the disappearance of well-defined grains after the combinations of HAP and MoO3, while graphene oxide (GO) caused a reduction in size and maintaining the particles’ shape. The combination between HAP/MoO3 declines the roughness of both HAP and MoO3 individually, recording 27.5 nm, while HAP/GO and HAP/MoO3/GO exhibit in-between roughness average (Ra) value among its raw constituents with 34.7 and 33.5 nm, respectively. Furthermore, SEM micrographs and roughness results show how to tailing the proper features for the proposed application by changing the type and amount of additives into HAP. Thus, the composite (HAP/MoO3/GO) displays the uppermost cell viability compared with the rest compositions with 97.8 ± 3.0%. Additionally, this triple composite hits the peak germicidal behavior with 17.9 ± 1.2 and 16.5 ± 0.9 mm against both E.coli and S.aureus, respectively.