Immune mediators of chronic pelvic pain syndrome

Chronic pelvic pain syndrome (CPPS) is the most common classification of prostatitis and affects up to 16% of men at some point in their livesCPPS is classified as an abacterial disease at time of diagnoses but acute bacterial infection might initiate inflammation and development of painLoss of regulation and suppression of CD4+ T-cell activity might result in constitutively active mast cells and loss of tolerance in CPPSMast-cell-released factors, such as tryptase and nerve growth factor, might mediate both inflammation and neural sensitizationCPPS has a complex aetiology, with evidence suggesting interplay between T cells, mast cells and neurons in the development of autoimmunity