Pharmacokinetics, Safety, and Tolerability of Intravenous Felbinac Trometamol in Healthy Chinese Volunteers: A First-in-Human Single- and Multiple-Dose Escalation Phase I Study with a Randomized, Double-Blind, Placebo-Controlled Design

被引：0
|
作者：
Min Wu
Cuiyun Li
Hong Zhang
Jixuan Sun
Xiaoxue Zhu
Xiaojiao Li
Xuedong Gao
Wei Wang
Yanhua Ding
机构：
[1] The First Hospital of Jilin University,Department of Phase I Clinical Trial Unit
[2] Shijiazhuang Yiling Pharmaceutical Co.,undefined
[3] Ltd,undefined
来源：
CNS Drugs | 2020年 / 34卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：867 / 877
页数：10
相关论文
共 50 条
  • [1] Pharmacokinetics, Safety, and Tolerability of Intravenous Felbinac Trometamol in Healthy Chinese Volunteers: A First-in-Human Single- and Multiple-Dose Escalation Phase I Study with a Randomized, Double-Blind, Placebo-Controlled Design
    Wu, Min
    Li, Cuiyun
    Zhang, Hong
    Sun, Jixuan
    Zhu, Xiaoxue
    Li, Xiaojiao
    Gao, Xuedong
    Wang, Wei
    Ding, Yanhua
    CNS DRUGS, 2020, 34 (08) : 867 - 877
  • [2] Safety, Tolerability, and Pharmacokinetics of Kukoamine B in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Phase I Study
    Zhao, Qian
    Liu, Hongzhong
    Wang, Zhenlei
    Wang, Teng
    Cui, Cheng
    Wang, Huanhuan
    Li, Lili
    Zhong, Wen
    Jiang, Ji
    Dong, Kai
    Chen, Shuai
    Jin, Chunyan
    Hu, Pei
    ADVANCES IN THERAPY, 2023, 40 (07) : 3186 - 3198
  • [3] Safety, Tolerability, and Pharmacokinetics of Kukoamine B in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Phase I Study
    Qian Zhao
    Hongzhong Liu
    Zhenlei Wang
    Teng Wang
    Cheng Cui
    Huanhuan Wang
    Lili Li
    Wen Zhong
    Ji Jiang
    Kai Dong
    Shuai Chen
    Chunyan Jin
    Pei Hu
    Advances in Therapy, 2023, 40 : 3186 - 3198
  • [4] A first-in-human, randomized, double-blind, single- and multiple-dose, phase I study of recombinant human thymosin β4 in healthy Chinese volunteers
    Wang, Xinghe
    Liu, Long
    Qi, Lu
    Lei, Chunpu
    Li, Pu
    Wang, Yu
    Liu, Chen
    Bai, Haihong
    Han, Chengquan
    Sun, Yinjian
    Liu, Jincan
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2021, 25 (17) : 8222 - 8228
  • [5] Pharmacokinetics, Safety, and Tolerability of Oxfendazole in Healthy Volunteers: a Randomized, Placebo-Controlled First-in-Human Single-Dose Escalation Study
    An, Guohua
    Murry, Daryl J.
    Gajurel, Kiran
    Bach, Thanh
    Deye, Greg
    Stebounova, Larissa, V
    Codd, Ellen E.
    Horton, John
    Gonzalez, Armando E.
    Garcia, Hector H.
    Ince, Dilek
    Hodgson-Zingman, Denice
    Nomicos, Effie Y. H.
    Conrad, Thomas
    Kennedy, Jessie
    Jones, Walt
    Gilma, Robert H.
    Winokur, Patricia
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2019, 63 (04)
  • [6] A phase I, randomized, double-blind, placebo-controlled, ascending single- and multiple-dose study of the pharmacokinetics, safety, and tolerability of oral ceftibuten in healthy adult subjects
    Hernandez-Mitre, Maria Patricia
    Wallis, Steven C.
    Morgan, Elizabeth E.
    Dudley, Michael N.
    Loutit, Jeffery S.
    Griffith, David C.
    Roberts, Jason A.
    Shields, Ryan K.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2024, 68 (01)
  • [7] First-in-human safety, tolerability, and pharmacokinetics of ammoxetine in healthy subjects: a randomized, double-blind, placebo-controlled phase I study
    Shen, Qi
    Hu, Chao
    Miao, Jia
    Chen, Junxia
    Peng, Yueying
    Pan, Tingting
    He, Xiaolin
    Yuan, Jing
    Ni, Shaonan
    Wang, Yongsheng
    Luo, Zhu
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021, 159
  • [8] Safety, tolerability, and pharmacokinetic of HY0721 in Chinese healthy subjects: A first-in-human randomized, double-blind, placebo-controlled dose escalation phase I study
    Zhang, Mengyu
    Liu, Runhan
    Wang, Ying
    Zhu, Xiaohong
    Wang, Zhenlei
    Li, Xiaoyu
    Zheng, Li
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2024, 200
  • [9] PHARMACOKINETICS, SAFETY AND TOLERABILITY OF SINGLE- AND MULTIPLE-DOSE ONCE-DAILY BARICITINIB IN CHINESE HEALTHY VOLUNTEERS - A RANDOMIZED PLACEBO-CONTROLLED STUDY
    Zhao, Xia
    Payne, Christopher
    Wang, Feng
    Cui, Yiming
    ANNALS OF THE RHEUMATIC DISEASES, 2019, 78 : 378 - 378
  • [10] Tolerability and Pharmacokinetics of Avanafil, a Phosphodiesterase Type 5 Inhibitor: A Single- and Multiple-Dose, Double-Blind, Randomized, Placebo-Controlled, Dose-Escalation Study in Healthy Korean Male Volunteers
    Jung, Jinah
    Choi, Sangmin
    Cho, Sang Heon
    Ghim, Jong-Lyul
    Hwang, Aekyung
    Kim, Unjib
    Kim, Bong Sik
    Koguchi, Atsushi
    Miyoshi, Shinji
    Okabe, Hirotaka
    Bae, Kyun-Seop
    Lim, Hyeong-Seok
    CLINICAL THERAPEUTICS, 2010, 32 (06) : 1178 - 1187
12345