Synthesis of 2-phenyl-4,5,6,7-tetrahydro-1H-indoles with a chiral substituent at the nitrogen atom

被引：0
|
作者：
I. A. Andreev
I. O. Ryzhkov
A. V. Kurkin
M. A. Yurovskaya
机构：
[1] M. V. Lomonosov State University,
来源：
Chemistry of Heterocyclic Compounds | 2012年 / 48卷
关键词：
2-phenyl-4,5,6,7-tetrahydro-1; -indoles; -amino propargylic alcohols; chiral substituent at nitrogen atom; palladium-catalyzed cyclization;
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学科分类号：
摘要：
An efficient method has been developed for the enantioselective synthesis of 2-phenyl-4,5,6,7-tetra-hydro-1H-indoles containing chiral substituents at the nitrogen atom. It is based on opening of the epoxide fragment of 1-phenylethynyl-7-oxabicyclo[4.1.0]heptane with chiral amines and/or amino acid esters followed by intramolecular, metal catalyzed cyclization.
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页码：715 / 719
页数：4
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