Raf promotes human herpesvirus-8 (HHV-8/KSHV) infection

被引：0
|
作者：
Shaw M Akula
Patrick W Ford
Audy G Whitman
Khalief E Hamden
John G Shelton
James A McCubrey
机构：
[1] Brody School of Medicine,Department of Microbiology & Immunology
[2] East Carolina University,undefined
来源：
Oncogene | 2004年 / 23卷
关键词：
HHV-8; KSHV; Raf; VEGF; HB-EGF;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Human herpesvirus-8 (HHV-8/KSHV) is etiologically associated with Kaposi's sarcoma (KS) and other tumors. Constitutive activation of the mitogen-activated protein kinase (MAPK) signaling pathway has been associated with a variety of tumors, including AIDS-related KS. The oncoprotein Raf is situated at a pivotal position in regulating the MAPK pathway. Hence, we analysed the effect of oncoprotein Raf on HHV-8 infectious entry into target cells. Here we report Raf expression to significantly enhance HHV-8 infection of target cells. These findings implicate a role for Raf not only in the infectious entry of HHV-8 but also in modulating KS pathogenesis.
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页码：5227 / 5241
页数：14
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