Chemotherapy induces Notch1-dependent MRP1 up-regulation, inhibition of which sensitizes breast cancer cells to chemotherapy

被引:0
|
作者
Baek Kim
Sam L. Stephen
Andrew M. Hanby
Kieran Horgan
Sarah L. Perry
Julie Richardson
Elizabeth A. Roundhill
Elizabeth M. A. Valleley
Eldo T. Verghese
Bethany J. Williams
James L. Thorne
Thomas A. Hughes
机构
[1] University of Leeds,School of Medicine
[2] Leeds Teaching Hospitals NHS Trust,Department of Breast Surgery
[3] Leeds Teaching Hospitals NHS Trust,Department of Histopathology
[4] University of Leeds,School of Food Science and Nutrition
来源
BMC Cancer | / 15卷
关键词
Doxorubicin; Notch Signalling; Calcein; T47D Cell; DAPT;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [1] Chemotherapy induces Notch1-dependent MRP1 up-regulation, inhibition of which sensitizes breast cancer cells to chemotherapy
    Kim, Baek
    Stephen, Sam L.
    Hanby, Andrew M.
    Horgan, Kieran
    Perry, Sarah L.
    Richardson, Julie
    Roundhill, Elizabeth A.
    Valleley, Elizabeth M. A.
    Verghese, Eldo T.
    Williams, Bethany J.
    Thorne, James L.
    Hughes, Thomas A.
    BMC CANCER, 2015, 15
  • [2] Modulation of MRP1 activity reverses chemotherapy resistance in adult cancer cells
    Hanssen, Kimberley M.
    Gana, Christine C.
    Wheatley, Madeleine S.
    Yu, Denise M.
    Flemming, Claudia L.
    Young, Richard
    Wright, Gavin M.
    Conseil, Gwenaelle
    Kennedy, Catherine J.
    deFazio, Anna
    Solomon, Ben
    Cole, Susan P.
    Norris, Murray D.
    Haber, Michelle
    Fletcher, Jamie I.
    CANCER RESEARCH, 2019, 79 (13)
  • [3] MRP1 but not MDR1 is associated with response to neoadjuvant chemotherapy in breast cancer patients
    Taheri, Mohsen
    Mahjoubi, Frouzandeh
    DISEASE MARKERS, 2013, 34 (06) : 387 - 393
  • [4] Rapamycin Inhibits IGF-1-Mediated Up-Regulation of MDM2 and Sensitizes Cancer Cells to Chemotherapy
    Du, Wei
    Yi, Yong
    Zhang, Haibo
    Bergholz, Johann
    Wu, Junfeng
    Ying, Haoqiang
    Zhang, Yujun
    Xiao, Zhi-Xiong Jim
    PLOS ONE, 2013, 8 (04):
  • [5] ALDH1A inhibition sensitizes colon cancer cells to chemotherapy
    Z. Kozovska
    A. Patsalias
    V. Bajzik
    E. Durinikova
    L. Demkova
    S. Jargasova
    B. Smolkova
    J. Plava
    L. Kucerova
    M. Matuskova
    BMC Cancer, 18
  • [6] ALDH1A inhibition sensitizes colon cancer cells to chemotherapy
    Kozovska, Z.
    Patsalias, A.
    Bajzik, V.
    Durinikova, E.
    Demkova, L.
    Jargasova, S.
    Smolkova, B.
    Plava, J.
    Kucerova, L.
    Matuskova, M.
    BMC CANCER, 2018, 18
  • [7] Expression of MRP1, LRP and Pgp in breast carcinoma patients treated with preoperative chemotherapy
    Margaretha Rudas
    Martin Filipits
    Susanne Taucher
    Thomas Stranzl
    Günther G. Steger
    Raimund Jakesz
    Robert Pirker
    Gudrun Pohl
    Breast Cancer Research and Treatment, 2003, 81 : 149 - 157
  • [8] Expression of MRP1, LRP and Pgp in breast carcinoma patients treated with preoperative chemotherapy
    Rudas, M
    Filipits, M
    Taucher, S
    Stranzl, T
    Steger, GG
    Jakesz, R
    Pirker, R
    Pohl, G
    BREAST CANCER RESEARCH AND TREATMENT, 2003, 81 (02) : 149 - 157
  • [9] Inhibition of PRMT5-mediated regulation of DKK1 sensitizes colorectal cancer cells to chemotherapy
    Abumustafa, Wafaa
    Castven, Darko
    Becker, Diana
    Salih, Shahenaz Shaban
    Manzoor, Shaista
    Zamer, Batoul Abi
    Talaat, Iman
    Hamad, Mawieh
    Marquardt, Jens Uwe
    Muhammad, Jibran Sualeh
    CELLULAR SIGNALLING, 2024, 119
  • [10] Correlations of MRP1 gene with serum TGF-β1 and IL-8 in breast cancer patients during chemotherapy
    Zhuang, Xiaoming
    Wang, Jingmei
    JOURNAL OF BUON, 2018, 23 (05): : 1302 - 1308