Ex vivo 18F-fluoride uptake and hydroxyapatite deposition in human coronary atherosclerosis

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作者
Alastair J. Moss
Alisia M. Sim
Philip D. Adamson
Michael A. Seidman
Jack P. M. Andrews
Mhairi K. Doris
Anoop S. V. Shah
Ralph BouHaidar
Carlos J. Alcaide-Corral
Michelle C. Williams
Jonathon A. Leipsic
Marc R. Dweck
Vicky E. MacRae
David E. Newby
Adriana A. S. Tavares
Stephanie L. Sellers
机构
[1] University of Edinburgh,BHF Centre for Cardiovascular Science, Chancellor’s Building
[2] University of Leicester,British Heart Foundation Cardiovascular Research Centre
[3] University of Edinburgh,EaStCHEM School of Chemistry
[4] University of Otago,Christchurch Heart Institute
[5] St Paul’s Hospital and University of British Columbia,Department of Pathology
[6] St Paul’s Hospital and University of British Columbia,Department of Radiology and Centre for Heart Lung Innovation
[7] University of Edinburgh,The Roslin Institute and Royal (Dick) School of Veterinary Studies
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摘要
Early microcalcification is a feature of coronary plaques with an increased propensity to rupture and to cause acute coronary syndromes. In this ex vivo imaging study of coronary artery specimens, the non-invasive imaging radiotracer, 18F-fluoride, was highly selective for hydroxyapatite deposition in atherosclerotic coronary plaque. Specifically, coronary 18F-fluoride uptake had a high signal to noise ratio compared with surrounding myocardium that makes it feasible to identify coronary mineralisation activity. Areas of 18F-fluoride uptake are associated with osteopontin, an inflammation-associated glycophosphoprotein that mediates tissue mineralisation, and Runt-related transcription factor 2, a nuclear protein involved in osteoblastic differentiation. These results suggest that 18F-fluoride is a non-invasive imaging biomarker of active coronary atherosclerotic mineralisation.
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