A Study of Chromosomal Aberrations and Chromosomal Fragility after Recombinant Growth Hormone Treatment

被引:0
|
作者
Arnold H Slyper
Jeffrey D Shadley
Peter Van Tuinen
Samuel M Richton
Raymond G Hoffmann
David T Wyatt
机构
[1] Medical College of Wisconsin,
[2] Miami Children's Hospital,undefined
来源
Pediatric Research | 2000年 / 47卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Increased chromosomal rearrangements and chromosomal fragility have been previously observed in lymphocytes of children treated with human GH, implying that treatment could predispose to malignancy. Twenty-four children with classic GH deficiency, neurosecretory GH dysfunction, and Turner syndrome were treated with recombinant human GH (0.3 mg·kg−1·wk−1). Metaphase cells were assessed for spontaneous chromosomal and chromatid aberrations at baseline and 6 mo into treatment. There were no significant differences in aberrations between baseline and the 6-mo samples. However, the mean frequency of chromatid-type aberrations on a per cell basis was significantly higher than at baseline, 0.0088 versus 0.0064 aberrations per cell (p < 0.024). Two patients contributed inordinately to this increase. A third sample from these two patients was almost identical to their baseline samples. Cells were also irradiated in vitro (3 Gy) to assess chromosomal fragility. After irradiation, no patient showed a significant difference for any aberration type, although there was a significantly lower frequency of ring chromosomes on a per cell basis in the 6-mo samples (p < 0.001). We find no evidence that GH therapy influences spontaneous chromosomal aberrations or chromosomal fragility.
引用
收藏
页码:634 / 639
页数:5
相关论文
共 50 条
  • [1] A study of chromosomal aberrations and chromosomal fragility after recombinant growth hormone treatment
    Slyper, AH
    Shadley, JD
    Van Tuinen, P
    Richton, SM
    Hoffmann, RG
    Wyatt, DT
    [J]. PEDIATRIC RESEARCH, 2000, 47 (05) : 634 - 639
  • [2] Zygotic chromosomal structural aberrations after paternal drug treatment
    Downey, Anne Marie
    Robaire, Bernard
    [J]. ASIAN JOURNAL OF ANDROLOGY, 2015, 17 (06) : 939 - 941
  • [3] CHROMOSOMAL ABERRATIONS FOR DIAGNOSIS AND PATIENT TREATMENT
    Ylstra, B.
    [J]. CELLULAR ONCOLOGY, 2010, 32 (03) : 173 - 173
  • [4] Does growth hormone treatment increase chromosomal abnormalities?
    Bozzola, M
    Tettoni, K
    Severi, F
    Capra, E
    Danesino, C
    Scappaticci, S
    [J]. CLINICAL ENDOCRINOLOGY, 1997, 47 (03) : 363 - 366
  • [5] Detection of chromosomal aberrations in cattle cells after conazole fungicide treatment
    Holeckova, B.
    Dianovsky, J.
    Sivikova, K.
    Mesarc, M.
    [J]. TOXICOLOGY LETTERS, 2010, 196 : S169 - S169
  • [6] Chromosomal aberrations as etiological factors of intrauterine growth retardation
    Petrovic, Bojana
    Ljubic, Aleksandar
    Nikolic, Ljubinka
    [J]. VOJNOSANITETSKI PREGLED, 2008, 65 (03) : 195 - 198
  • [7] CHROMOSOMAL-ABERRATIONS AND NEOPLASM - FAMILY STUDY
    WURSTERH.DH
    CORNWELL, GG
    MCINTYRE, OR
    [J]. CANCER, 1974, 33 (01) : 72 - 81
  • [8] CHROMOSOMAL-ABERRATIONS AFTER SUPER-OVULATION
    KOIDE, N
    KAMIGUCHI, Y
    MIKAMO, K
    [J]. JAPANESE JOURNAL OF HUMAN GENETICS, 1979, 24 (03): : 192 - 192
  • [9] CHROMOSOMAL ABERRATIONS IN PERNICIOUS ANEMIA - STUDY OF 3 CASES BEFORE AND AFTER THERAPY
    KIOSSOGLOU, KA
    MITUS, WJ
    DAMESHEK, W
    [J]. BLOOD-THE JOURNAL OF HEMATOLOGY, 1965, 25 (05): : 662 - +
  • [10] ULTRASONIC GROWTH-PATTERN OF FETUSES WITH CHROMOSOMAL-ABERRATIONS
    KURJAK, A
    KIRKINEN, P
    [J]. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 1982, 61 (03) : 223 - 225