Single-cell analysis reveals transcriptional heterogeneity of neural progenitors in human cortex

被引：0
|
作者：
Matthew B Johnson
Peter P Wang
Kutay D Atabay
Elisabeth A Murphy
Ryan N Doan
Jonathan L Hecht
Christopher A Walsh
机构：
[1] Boston Children's Hospital,Division of Genetics and Genomics
[2] Manton Center for Orphan Disease Research,Department of Pathology
[3] Boston Children's Hospital,Department of Pathology
[4] Howard Hughes Medical Institute,Department of Pediatrics
[5] Boston Children's Hospital,Department of Neurology
[6] Beth Israel Deaconess Medical Center,undefined
[7] Harvard Medical School,undefined
[8] Harvard Medical School,undefined
[9] Harvard Medical School,undefined
[10] Program in Medical and Population Genetics,undefined
[11] Broad Institute of MIT and Harvard,undefined
来源：
Nature Neuroscience | 2015年 / 18卷
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摘要：
The developing human cortex contains diverse populations of neural progenitor cells, including a large proportion of outer radial glia (ORG), a progenitor type that is rare in the mouse. The authors identify a transcriptional signature of ORG characterized by markers of neuronal lineage fate and use single-cell analyses to contrast the heterogeneity of cortical progenitors across human, mouse and ferret.
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页码：637 / 646
页数：9
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