Sarcoma molecular testing: Diagnosis and prognosis

被引：7
|
作者：
Lazar A.J.F. [1 ]
Trent J.C. [1 ]
机构：
[1] Department of Pathology, Sarcoma Research Center, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030-4009
来源：
Current Oncology Reports | 2007年 / 9卷 / 4期
关键词：
Sarcoma; Imatinib; Synovial Sarcoma; Desmoid Tumor; Ewing Sarcoma;
D O I：
10.1007/s11912-007-0038-8
中图分类号：
学科分类号：
摘要：
Methodologies employed in the rapidly developing field of soft tissue sarcoma molecular testing focus primarily on diagnosis using chromosomal translocations and the resulting fusion transcripts. Molecular prognostic testing holds promise in this complex group of rare mesenchymal malignancies, but results are preliminary and require further confirmation. Analysis of activating KIT mutations in gastrointestinal stromal tumors is currently being used in management of patient therapy. Copyright © 2007 by Current Medicine Group LLC.
引用
收藏
页码：309 / 315
页数：6
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