β-adrenergic receptor desensitization in cardiac hypertrophy and heart failure

被引：0

作者：

Dong-Ju Choi

Howard A. Rockman

机构：

[1] University of North Carolina at Chapel Hill,Department of Medicine

[2] Gyeong-Sang National University,Department of Medicine and Cardiovascular Research Institute

来源：

Cell Biochemistry and Biophysics | 1999年 / 31卷

关键词：

Carvedilol; Cardiac Hypertrophy; Cell Biochemistry; Biophysics Volume; Adenylyl Cyclase Activity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Based on our recent data (37,54,56) and the association that profound alterations in βAR signaling are found in chronic end-stage human heart failure (64), it is possible that defects in this pathway are primary elements that underlie the transition from compensated to decompensated cardiac failure. Decreasing the level of myocardial βARK1 in established heart failure, is a novel approach to improving impaired βAR receptor function and potentially alter the pathogenesis in this disease.

引用

页码：321 / 329

页数：8

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