Effects of Rifaximin on Bacterial Translocation in Thioacetamide-Induced Liver Injury in Rats

被引：0
|
作者：
Murat M. M. Harputluoglu
Ulvi Demirel
Mehmet Gul
Ismail Temel
Sule Gursoy
Engin Burak Selcuk
Murat Aladag
Yilmaz Bilgic
Ercan Gunduz
Yuksel Seckin
机构：
[1] Inonu University Medical Faculty,Department of Gastroenterology
[2] Firat University Medical Faculty,Department of Gastroenterology
[3] Inonu University Medical Faculty,Department of Histology and Embryology
[4] Inonu University Medical Faculty,Department of Biochemistry
[5] Inonu University Medical Faculty,Department of Family Medicine
[6] Inonu University Medical Faculty,Department of Internal Medicine
来源：
Inflammation | 2012年 / 35卷
关键词：
rifaximin; bacterial translocation; thioacetamide; liver injury;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Intestinal bacterial overgrowth (IBO) and increased mucosal permeability are suggested to increase bacterial translocation (BT) in liver injury. Rifaximin (RIF) is a minimally absorbed oral antimicrobial agent that restores gut microflora imbalance. The aim of the present study was to investigate the effects of RIF on BT frequency in thioacetamide (TAA)-induced liver injury. Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3 days. In group 3 (TAA + RIF), RIF was commenced on the same day as the first dose of TAA. In group 4 (RIF), rats received only RIF. Ileal aspirate Escherichia coli counts were significantly lower in the TAA + RIF group than in TAA group. There was no difference in BT frequency between the TAA and TAA + RIF groups. Our results suggest that factors such as intestinal barrier dysfunction and impaired host immune shield, apart from IBO, play an important role in BT in this model.
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页码：1512 / 1517
页数：5
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