Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9

被引：0

作者：

Umeharu Ohto

Takuma Shibata

Hiromi Tanji

Hanako Ishida

Elena Krayukhina

Susumu Uchiyama

Kensuke Miyake

Toshiyuki Shimizu

机构：

[1] Graduate School of Pharmaceutical Sciences,Division of Innate Immunity, Department of Microbiology and Immunology

[2] The University of Tokyo,undefined

[3] Hongo,undefined

[4] Bunkyo-ku,undefined

[5] Tokyo 113-0033,undefined

[6] Japan,undefined

[7] Laboratory of Innate Immunity,undefined

[8] Center for Experimental Medicine and Systems Biology,undefined

[9] The Institute of Medical Science,undefined

[10] The University of Tokyo,undefined

[11] 4-6-1 Shirokanedai,undefined

[12] Minato-ku,undefined

[13] Tokyo 108-8639,undefined

[14] Japan,undefined

[15] Core Research for Evolutional Science and Technology (CREST),undefined

[16] Japan Science and Technology Agency (JST),undefined

[17] Saitama 332-0012,undefined

[18] Japan,undefined

[19] Graduate School of Engineering,undefined

[20] Osaka University,undefined

[21] 2-1 Yamadaoka,undefined

[22] Suita,undefined

[23] Osaka 565-0871,undefined

[24] Japan,undefined

[25] U-Medico Corporation,undefined

[26] 2-1 Yamadaoka,undefined

[27] Suita,undefined

[28] Osaka 565-0871,undefined

[29] Japan,undefined

来源：

Nature | 2015年 / 520卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Crystal structures of three forms of Toll-like receptor (TLR) 9 — unliganded or bound either to immune stimulatory CpG-containing DNA or inhibitory DNA — together reveal the molecular basis of TLR9 activation.

引用

页码：702 / 705

页数：3

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