Anti-hyperglycemic and hypolipidemic effects of baechukimchi with Ecklonia cava in type 2 diabetic db/db mice

Anti-hyperglycemic and hypolipidemic effects of baechukimchi with Ecklonia cava were investigated in type 2 diabetic db/db mice. Baechukimchi with 15% added E. cava (BKE) was fermented at 5°C for 28 days to obtain optimally ripened BKE (pH 4.28, acidity 0.71). BKE was subjected to extraction using 80% methanol. Male db/db mice were divided into groups of db/db-control, db/db-BKE, and db/db-rosiglitazone (db/db-RG). Compounds were orally administered every day for 6 weeks. The db/db-BKE mice had lowered blood glucose and plasma insulin levels. Plasma total cholesterol, triglyceride, and LDL-cholesterol levels in db/db-BKE mice were significantly (p<0.05) decreased, compared with untreated db/db mice, while db/db-BKE mice had significantly (p<0.05) increased HDL-cholesterol levels. The db/db-BKE mice had significantly (p<0.05) decreased levels of liver total cholesterol and triglyceride. BKE significantly (p<0.05) increased antioxidant enzyme activities, and ROS and lipid peroxidation levels were significantly (p<0.05) lower in db/db-BKE mice than in db/db mice.