Effects of NMDA-Receptor Antagonist Treatment on c-fos Expression in Rat Brain Areas Implicated in Schizophrenia

被引:0
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作者
Jussi Väisänen
Jouni Ihalainen
Heikki Tanila
Eero Castrén
机构
[1] University of Kuopio,A.I. Virtanen Institute
[2] University of Kuopio,Department of Psychiatry
[3] University of Kuopio,Department of Neuroscience and Neurology
[4] University of Helsinki,Neuroscience Center
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关键词
schizophrenia; MK801; neural circuits; NMDA;
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摘要
1. The noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonists produce behavioral responses that closely resemble both positive and negative symptoms of schizophrenia. These drugs also induce excitatory and neurotoxic effects in limbic cortical areas.
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页码:769 / 780
页数:11
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