UFT/leucovorin and oxaliplatin alternated with UFT/leucovorin and irinotecan in metastatic colorectal cancer

被引：0
|
作者：
R Petrioli
M Sabatino
A I Fiaschi
S Marsili
D Pozzessere
S Messinese
P Correale
S Civitelli
G Tanzini
F Tani
A De Martino
G Marzocca
M Lorenzi
G Giorgi
G Francini
机构：
[1] Medical Oncology Section,Department of Human Pathology and Oncology
[2] University of Siena,Department of Pharmacology
[3] Viale Bracci 11,undefined
[4] University of Siena,undefined
[5] Clinical Surgery,undefined
[6] University of Siena,undefined
[7] General Surgery,undefined
[8] University of Siena,undefined
来源：
British Journal of Cancer | 2004年 / 90卷
关键词：
colorectal cancer; irinotecan; oxaliplatin; tegafur/uracil;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A total of 41 metastatic colorectal cancer (CRC) patients received tegafur/uracil (UFT)+leucovorin (LV)+oxaliplatin alternated with UFT/LV+irinotecan. The overall response rate was 58.5% (95% confidence interval, 42.2–73.3%), and the median progression-free survival was 8.8 months. There were no grade 4 toxicities; 12 patients (29%) experienced grade 3 diarrhoea. There were no cases of hand–foot syndrome. This alternating regimen seems to be effective and well tolerated in the first-line treatment of patients with metastatic CRC.
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页码：306 / 309
页数：3
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