Antiinflammatory and immunomodulatory properties of statins

被引：0
|
作者：
Ora Shovman
Yair Levy
Boris Gilburd
Yehuda Shoenfeld
机构：
[1] Tel-Hashomer 52621 Sackler Faculty of Medicine Tel-Aviv University,Department of Medicine B, Sheba Medical Center
来源：
Immunologic Research | 2002年 / 25卷
关键词：
Atherosclerosis; Immune system; Statins; Monocytes; Endothelial cells; Lymphocytes; Smooth Muscle cells;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase or stains constitute the most powerful class of lipid lowering drugs, widely used in medical practice. During the past several years additional actions of statins unrel ated to cholesterol reduction have been identified which includes antiinflammatory and immunomodulatory properties. Since atherosclerosis is a form of inflammation and the immune system play an important role in its pathogenesis, pleiotropic effect of statins may provide complementary explanation to their clinical benefit. This article reviews the data regarding the antiinflammatory and immunomodulatory properties of the statins that are available in the treatment of atherosclerosis and possibly may be applicable in other inflammatory diseases or conditions with the involvement of the immune system.
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页码：271 / 285
页数：14
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