Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α

被引：0
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作者：
Gonzalo Viana Di Prisco
Wei Huang
Shelly A Buffington
Chih-Chun Hsu
Penelope E Bonnen
Andon N Placzek
Carmela Sidrauski
Krešimir Krnjević
Randal J Kaufman
Peter Walter
Mauro Costa-Mattioli
机构：
[1] Baylor College of Medicine,Department of Neuroscience
[2] Memory and Brain Research Center,Department of Molecular and Human Genetics
[3] Baylor College of Medicine,Department of Biochemistry and Biophysics
[4] Baylor College of Medicine,Department of Physiology
[5] Howard Hughes Medical Institute,undefined
[6] University of California San Francisco,undefined
[7] McGill University,undefined
[8] Center for Neuroscience,undefined
[9] Aging,undefined
[10] and Stem Cell Research,undefined
[11] Sanford-Burnham Medical Research Institute,undefined
[12] Present address: Division of Basic Medical Sciences,undefined
[13] Mercer University School of Medicine,undefined
[14] Macon,undefined
[15] Georgia,undefined
[16] USA.,undefined
来源：
Nature Neuroscience | 2014年 / 17卷
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摘要：
The authors show that phosphorylation of the translation factor eIF2α is necessary and sufficient for mGluR-LTD. They identify mRNAs that are translated during mGluR-LTD and regulated by p-eIF2α, including Ophn1 as a key target. Deficient p-eIF2α-mediated translation impairs object-place learning, which requires mGluR-LTD. eIF2α phosphorylation may determine whether synapses undergo LTD or LTP.
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页码：1073 / 1082
页数：9
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