Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia

被引：0
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作者：
Katherine Laiton-Donato
Diego A. Alvarez
Dioselina Peláez-Carvajal
Marcela Mercado
Nadim J. Ajami
Irene Bosch
José A. Usme-Ciro
机构：
[1] Grupo de Virología,Dirección de Vigilancia y Análisis del Riesgo en Salud Pública
[2] Dirección de Redes en Salud Pública,undefined
[3] Instituto Nacional de Salud,undefined
[4] Instituto Nacional de Salud,undefined
[5] Alkek Center for Metagenomics and Microbiome Research,undefined
[6] Baylor College of Medicine,undefined
[7] Institute for Medical Engineering and Science,undefined
[8] Massachusetts Institute of Technology,undefined
[9] Current Address: Centro de Investigación en Salud para el Trópico - CIST,undefined
[10] Facultad de Medicina,undefined
[11] Universidad Cooperativa de Colombia,undefined
[12] Troncal del Caribe Sector Mamatoco,undefined
来源：
Virology Journal | / 16卷
关键词：
Dengue virus; Molecular characterization; Phylogeny; Envelope; Evolution;
D O I：
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摘要：
Dengue is hyperendemic in Colombia, where a cyclic behavior of serotype replacement leading to periodic epidemics has been observed for decades. This level of endemicity favors accumulation of dengue virus genetic diversity and could be linked to disease outcome. To assess the genetic diversity of dengue virus type 2 in Colombia, we sequenced the envelope gene of 24 virus isolates from acute cases of dengue or severe dengue fever during the period 2013–2016. The phylogenetic analysis revealed the circulation of the Asian-American genotype of dengue virus type 2 in Colombia during that period, the intra-genotype variability leading to divergence in two recently circulating lineages with differential geographic distribution, as well as the presence of nonsynonymous substitutions accompanying their emergence and diversification.
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