Effect of TGF-β1 on the expression of IL-12, IL-15, IL-18, IL-4 and IL-10 in heart transplantation rejection in rats

被引：0
|
作者：
Jinping Zhao
Ping Li
Sihai Gao
Xianguo Wang
Xiaojian Gao
机构：
[1] Huazhong University of Science and Technology,Department of Thoracic and Cardiac Surgery, Tongji Hospital, Tongji Medical College
[2] Huazhong University of Science and Technology,Department of Cardiac Surgery, Union Hospital, Tongji Medical College
来源：
Journal of Huazhong University of Science and Technology [Medical Sciences] | 2007年 / 27卷
关键词：
heart transplantation; TGF-β1; rejection; cytokines;
D O I：
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中图分类号：
学科分类号：
摘要：
To investigate the effect of TGF-β1 on the expressions of IL-12, IL-15, IL-18, IL-4 and IL-10 in heart transplantation rejection in rats, a model of rat cervical heterotopic heart transplantation was set up and the model rats were randomly divided into three groups: control group, transplant group and TGF-β1 group. The mRNA expression levels of IL-12, IL-15, IL-18, IL-4 and IL-10 were determined by RT-PCR at the 5th day after the transplantation. The mRNA expression levels of IL-12, IL-15, IL-18 were increased obviously and those of IL-4, IL-10 were significantly decreased in the transplant group as compared with the control group (P<0.01). In the TGF-β1 group, the mRNA expression levels of IL-12, IL-15, IL-18 were significantly decreased and those of IL-4, IL-10 were significantly increased as compared with the transplant group (P<0.01). The immunosuppressive effect of TGF-β1 on heart transplantation rejection was related to its inhibition of the expressions of Th1-type cytokines (IL-12, IL-15, IL-18 etc) and its promotion of the expressions of Th2-tpye cytokines (IL-4, IL-10).
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页码：643 / 645
页数：2
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