Blood tacrolimus concentrations in bone marrow transplant patients undergoing plasmapheresis

被引：0
|
作者：
GA Hale
DE Reece
RK Munn
AB Kniska
GL Phillips
机构：
[1] Markey Cancer Center,Division of Blood and Marrow Transplantation
[2] University of Kentucky,undefined
来源：
Bone Marrow Transplantation | 2000年 / 25卷
关键词：
tacrolimus; plasmapheresis; pharmacokinetics; GVHD; BMT; microangiopathic hemolytic anemia;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Microangiopathic hemolytic anemia (MAHA) is a well-described complication of stem cell transplantation. Plasmapheresis is one modality utilized as therapy for patients who develop this complication. However, plasmapheresis may alter whole blood levels of certain medications and its effect on tacrolimus in bone marrow transplant patients is unknown. Because tacrolimus has a narrow therapeutic range, the effect of plasmapheresis on whole blood concentrations would be important to know. We report three allogeneic BMT patients who were receiving tacrolimus as acute GVHD therapy while undergoing plasmapheresis for MAHA. Tacrolimus levels seemed unaffected by plasmapheresis in these patients. Bone Marrow Transplantation (2000) 25, 449–451.
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页码：449 / 451
页数：2
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