Novel Bis(1,2,4-oxadiazolyl) Fused Thiazole Derivatives: Synthesis and Anticancer Activity

被引：0
|
作者：
P. Sateesh Kumar
P. Umadevi
机构：
[1] Gitam University,Department of Chemistry, Gitam Institute of Sciences
来源：
Russian Journal of General Chemistry | 2018年 / 88卷
关键词：
benzothiazole; NSC 710305; proxazole; anticancer activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A novel series of bis-1,2,4-oxadiazole fused benzothiazole derivatives 9a–9j are synthesized, and their structures are confirmed by 1H and 13C NMR, and mass spectral data. All products are evaluated in vitro for their anticancer potential against a panel of four human cancer cell lines such as lung cancer (A549), breast carcinoma (MCF-7), melanoma (A375), and colon cancer (HT-29). The combretastatin-A4 is used as standard drug. All compounds 9a–9j exhibit significant anticancer activity with IC50 values ranging from 0.11±0.01 to 14.6±3.89 μM. Among these, compounds 9a–9d, 9h, 9i demonstrate more potent activity than the control.
引用
收藏
页码：2611 / 2615
页数：4
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