The paradox of care in behavioral epigenetics: Constructing early-life adversity in the lab

被引:0
|
作者
Martine Lappé
机构
[1] New York State Psychiatric Institute,Center for Research on Ethical, Legal and Social Implications of Psychiatric, Neurologic and Behavioral Genetics
来源
BioSocieties | 2018年 / 13卷
关键词
Behavioral epigenetics; Care; Early-life adversity; Knowledge production; Feminist science studies; Laboratory ethnography;
D O I
暂无
中图分类号
学科分类号
摘要
Many epigenetic studies focus on how stress, trauma, and care become molecularly embodied, affect gene expression without changing DNA sequence, and produce changes that influence the health and behavior of individuals, their offspring, and future generations. This article describes how care has become central in research on the epigenetic effects of early-life adversity. My analysis draws on ethnographic research in a behavioral epigenetics laboratory in the United States. Building on traditions in feminist science studies, I document how care is enacted with research samples, experimental protocols, and behavioral endpoints in experiments with model organisms. My findings point to tensions between researchers’ care for the data and their measurement of adversity as a discrete variable in the form of maternal interaction, neglect, and abuse in mice. I argue that these tensions suggest a ‘paradox of care’ that is actively shaping how epigenetic knowledge is produced and its impacts both within and beyond the lab, including for understandings of how early-life experiences shape human health, and our social expectations of mothers. This study suggests that more complex explanations of health and development promised by epigenetics are simultaneously constructed and constrained by caring practices in the laboratory.
引用
收藏
页码:698 / 714
页数:16
相关论文
共 50 条
  • [1] The paradox of care in behavioral epigenetics: Constructing early-life adversity in the lab
    Lappe, Martine
    [J]. BIOSOCIETIES, 2018, 13 (04) : 698 - 714
  • [2] Early-life adversity, epigenetics, and visceral hypersensitivity
    Liu, S.
    Hagiwara, S. I.
    Bhargava, A.
    [J]. NEUROGASTROENTEROLOGY AND MOTILITY, 2017, 29 (09):
  • [3] Epigenetic and Behavioral Outcomes Associated with Early-Life Adversity
    Roth, Tania
    [J]. BIOLOGICAL PSYCHIATRY, 2017, 81 (10) : S200 - S200
  • [4] Epigenetics of early-life adversity in youth: cross-sectional and longitudinal associations
    Jennifer A. Sumner
    Simone Gambazza
    Xu Gao
    Andrea A. Baccarelli
    Monica Uddin
    Katie A. McLaughlin
    [J]. Clinical Epigenetics, 2022, 14
  • [5] Epigenetics of early-life adversity in youth: cross-sectional and longitudinal associations
    Sumner, Jennifer A.
    Gambazza, Simone
    Gao, Xu
    Baccarelli, Andrea A.
    Uddin, Monica
    McLaughlin, Katie A.
    [J]. CLINICAL EPIGENETICS, 2022, 14 (01)
  • [6] Mitochondria and early-life adversity
    Zitkovsky, Emily K.
    Daniels, Teresa E.
    Tyrka, Audrey R.
    [J]. MITOCHONDRION, 2021, 57 : 213 - 221
  • [7] Using Principles of Behavioral Epigenetics to Advance Research on Early-Life Stress
    Conradt, Elisabeth
    [J]. CHILD DEVELOPMENT PERSPECTIVES, 2017, 11 (02) : 107 - 112
  • [8] Neuroinflammation, Early-Life Adversity, and Brain Development
    Andersen, Susan L.
    [J]. HARVARD REVIEW OF PSYCHIATRY, 2022, 30 (01) : 24 - 39
  • [9] Early-Life Experience, Epigenetics, and the Developing Brain
    Marija Kundakovic
    Frances A Champagne
    [J]. Neuropsychopharmacology, 2015, 40 : 141 - 153
  • [10] The Long Shadow of Exposure to Early-Life Adversity
    Niehoff, Debra
    Bradshaw, Catherine P. P.
    [J]. VIOLENCE AND GENDER, 2023, 10 (02) : 71 - 72