T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

被引：0

作者：

Vanja Lazarevic

Xi Chen

Jae-Hyuck Shim

Eun-Sook Hwang

Eunjung Jang

Alexandra N Bolm

Mohamed Oukka

Vijay K Kuchroo

Laurie H Glimcher

机构：

[1] Harvard School of Public Health,Department of Immunology and Infectious Diseases

[2] College of Pharmacy,Division of Life and Pharmaceutical Sciences

[3] Ewha Womans University,Department of Pediatrics

[4] Seattle Children's Research Institute,Department of Medicine

[5] Center for Neurologic Diseases,undefined

[6] Brigham & Women's Hospital,undefined

[7] Harvard Medical School,undefined

[8] and the Ragon Institute of MGH,undefined

[9] MIT and Harvard,undefined

来源：

Nature Immunology | 2011年 / 12卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Transcription factors specific for helper T cell lineages, such as T-bet, counter-regulate helper T cell development, but the details of this remain unclear. Glimcher and colleagues unravel the molecular basis of the regulation of TH17 cells by T-bet.

引用

页码：96 / 104

页数：8

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