New insights to the MLL recombinome of acute leukemias

被引：0

作者：

C Meyer

E Kowarz

J Hofmann

A Renneville

J Zuna

J Trka

R Ben Abdelali

E Macintyre

E De Braekeleer

M De Braekeleer

E Delabesse

M P de Oliveira

H Cavé

E Clappier

J J M van Dongen

B V Balgobind

M M van den Heuvel-Eibrink

H B Beverloo

R Panzer-Grümayer

A Teigler-Schlegel

J Harbott

E Kjeldsen

S Schnittger

U Koehl

B Gruhn

O Heidenreich

L C Chan

S F Yip

M Krzywinski

C Eckert

A Möricke

M Schrappe

C N Alonso

B W Schäfer

J Krauter

D A Lee

U zur Stadt

G Te Kronnie

R Sutton

S Izraeli

L Trakhtenbrot

L Lo Nigro

G Tsaur

L Fechina

T Szczepanski

S Strehl

D Ilencikova

M Molkentin

T Burmeister

T Dingermann

机构：

[1] Diagnostic Center of Acute Leukemia,Department of Hematology

[2] Institute of Pharmaceutical Biology,Department of Paediatric Haematology/Oncology

[3] ZAFES,Département de Génétique

[4] University of Frankfurt,Department of Immunology

[5] Biology and Pathology Center,Department of Pediatric Oncology/Hematology

[6] CHU of Lille,Department of Clinical Genetics

[7] INSERM,Department of Pediatric Hematology and Oncology

[8] U-837,Department of Pediatric Hematology and Oncology

[9] Team 3,Department of Pediatrics

[10] CLIP,Department of Pathology

[11] Second Faculty of Medicine,Department of Pediatric Oncology and Hematology

[12] Charles University Prague,Department of Paediatrics

[13] Biological Hematology,Department of Oncology

[14] AP-HP Necker,Division of Pediatrics

[15] UniversitéParis Descartes,Department of Pediatric Hematology and Oncology

[16] Faculté de Médecine et des Sciences de la Santé,Department of Paediatrics and Oncohematology

[17] Laboratoire d'Histologie,Department of Pediatric Hemato

[18] Embryologie et Cytogénétique,Oncology

[19] Université de Bretagne Occidentale,Department of Pediatric Hematology and Oncology

[20] INSERM-U613,Department of Clinical Genetics

[21] CHU Purpan,undefined

[22] Laboratoire d’Hématologie,undefined

[23] Pediatric Hematology-Oncology Program,undefined

[24] Research Center,undefined

[25] Instituto Nacional de Cancer Rio de Janeiro,undefined

[26] Hopital Robert Debré,undefined

[27] Erasmus MC,undefined

[28] Sophia Children's Hospital,undefined

[29] Erasmus MC,undefined

[30] Sophia Children's Hospital,undefined

[31] Erasmus MC,undefined

[32] Children's Cancer Research Institute,undefined

[33] Children's University Hospital,undefined

[34] Cancercytogenetics Laboratory,undefined

[35] Aarhus University Hospital,undefined

[36] MLL Munich Leukemia Laboratory,undefined

[37] University of Frankfurt,undefined

[38] University of Jena,undefined

[39] Northern Institute for Cancer Research,undefined

[40] Newcastle University,undefined

[41] Queen Mary Hospital,undefined

[42] The University of Hong Kong,undefined

[43] Canada's Michael Smith Genome Sciences Center,undefined

[44] Charité Medical University Berlin,undefined

[45] CVK,undefined

[46] University of Schleswig-Holstein,undefined

[47] Servcio de Hemato-Oncología,undefined

[48] Hospital Nacional de Pediatría Prof Dr JP Garrahan,undefined

[49] University Children's Hospital,undefined

[50] Clinic for Hematology,undefined

来源：

Leukemia | 2009年 / 23卷

关键词：

translocations partner genes; acute leukemia; ALL; AML;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Chromosomal rearrangements of the human MLL gene are associated with high-risk pediatric, adult and therapy-associated acute leukemias. These patients need to be identified, treated appropriately and minimal residual disease was monitored by quantitative PCR techniques. Genomic DNA was isolated from individual acute leukemia patients to identify and characterize chromosomal rearrangements involving the human MLL gene. A total of 760 MLL-rearranged biopsy samples obtained from 384 pediatric and 376 adult leukemia patients were characterized at the molecular level. The distribution of MLL breakpoints for clinical subtypes (acute lymphoblastic leukemia, acute myeloid leukemia, pediatric and adult) and fused translocation partner genes (TPGs) will be presented, including novel MLL fusion genes. Combined data of our study and recently published data revealed 104 different MLL rearrangements of which 64 TPGs are now characterized on the molecular level. Nine TPGs seem to be predominantly involved in genetic recombinations of MLL: AFF1/AF4, MLLT3/AF9, MLLT1/ENL, MLLT10/AF10, MLLT4/AF6, ELL, EPS15/AF1P, MLLT6/AF17 and SEPT6, respectively. Moreover, we describe for the first time the genetic network of reciprocal MLL gene fusions deriving from complex rearrangements.

引用

页码：1490 / 1499

页数：9

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[1] New insights to the MLL recombinome of acute leukemias
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