Role of TIM-3 in ovarian cancer

被引：0
|
作者：
Y. Xu
H. Zhang
Y. Huang
X. Rui
F. Zheng
机构：
[1] The Third Affiliated Hospital of Soochow University,Department of Gynecology
[2] University of South Florida,Department of Epidemiology and Biostatistics, College of Public Health
来源：
Clinical and Translational Oncology | 2017年 / 19卷
关键词：
TIM-3; Ovarian cancer; Blockade;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Evidences have suggested that immunotherapy for ovarian cancer is effective. Immune checkpoints have emerged in the field of cancer immunotherapy. Multiple studies have shown negative regulation of TIM-3 expression on CD4+ and CD8+ T cells and other immunocytes. Overexpression of TIM-3 in innate immune cells has been found in certain types of tumor. The blockade of TIM-3 leads to sustained anti-tumor reactions. TIM-3 plays an inhibitive role for immunity in ovarian cancer. TIM-3 is involved in the development of various subtypes of ovarian cancer and thus has the potential to be a therapeutic target for treatment of ovarian cancer.
引用
收藏
页码：1079 / 1083
页数：4
相关论文
共 50 条
  • [1] Role of TIM-3 in ovarian cancer
    Xu, Y.
    Zhang, H.
    Huang, Y.
    Rui, X.
    Zheng, F.
    [J]. CLINICAL & TRANSLATIONAL ONCOLOGY, 2017, 19 (09): : 1079 - 1083
  • [2] Role of TIM-3 in ovarian cancer: the forsaken cop or a new noble
    Chang, Xiangyu
    Miao, Jinwei
    [J]. FRONTIERS IN IMMUNOLOGY, 2024, 15
  • [3] The Role of TIM-3 and LAG-3 in the Microenvironment and Immunotherapy of Ovarian Cancer
    Kozlowski, Mateusz
    Borzyszkowska, Dominika
    Cymbaluk-Ploska, Aneta
    [J]. BIOMEDICINES, 2022, 10 (11)
  • [4] The Expression of Tim-3 in Peripheral Blood of Ovarian Cancer
    Wu, Jie
    Liu, Cuiying
    Qian, Shao
    Hou, Hongchun
    [J]. DNA AND CELL BIOLOGY, 2013, 32 (11) : 648 - 653
  • [5] TIM-3 Dictates Functional Orientation of the Immune Infiltrate in Ovarian Cancer
    Fucikova, Jitka
    Rakova, Jana
    Hensler, Michal
    Kasikova, Lenka
    Belicova, Lucie
    Hladikova, Kamila
    Truxova, Iva
    Skapa, Petr
    Laco, Jan
    Pecen, Ladislav
    Praznovec, Ivan
    Halaska, Michael J.
    Brtnicky, Tomas
    Kodet, Roman
    Fialova, Anna
    Pineau, Josephine
    Gey, Alain
    Tartour, Eric
    Ryska, Ales
    Galluzzi, Lorenzo
    Spisek, Radek
    [J]. CLINICAL CANCER RESEARCH, 2019, 25 (15) : 4820 - 4831
  • [6] TIM-3 expression in breast cancer
    Burugu, Samantha
    Gao, Dongxia
    Leung, Samuel
    Chia, Stephen K.
    Nielsen, Torsten O.
    [J]. ONCOIMMUNOLOGY, 2018, 7 (11):
  • [7] Role of TIM-3/Galectin-9 pathway in lung cancer
    Ohue, Yoshihiro
    Kurose, Koji
    Nishio, Yumi
    Isobe, Midori
    Oka, Mikio
    Nakayama, Eiichi
    [J]. CANCER IMMUNOLOGY RESEARCH, 2016, 4 (11)
  • [8] Defining the role of Tim-3 in T cells
    Avery, Lyndsay
    Kane, Lawrence P.
    [J]. JOURNAL OF IMMUNOLOGY, 2016, 196
  • [9] TIM-3, a promising target for cancer immunotherapy
    He, Yayi
    Cao, Jie
    Zhao, Chao
    Li, Xuefei
    Zhou, Caicun
    Hirsch, Fred R.
    [J]. ONCOTARGETS AND THERAPY, 2018, 11 : 7005 - 7009
  • [10] TIM-3 pathway dysregulation and targeting in cancer
    Zeidan, Amer M.
    Komrokji, Rami S.
    Brunner, Andrew M.
    [J]. EXPERT REVIEW OF ANTICANCER THERAPY, 2021, 21 (05) : 523 - 534
12345