Multi-author Review¶Epigenetic control of transcription¶Introduction: the genetics of epigenetics

被引：0
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作者：
S. M. Gasser
R. Paro
F. Stewart
R. Aasland
机构：
[1] Swiss Institute for Experimental Cancer Research,
[2] CH-1066 Epalinges/Lausanne (Switzerland),undefined
[3] Fax +41 21 652 69 33,undefined
[4] e-mail: sgasser@eliot.unil.ch,undefined
[5] ZMBH,undefined
[6] University of Heidelberg,undefined
[7] Im Neuenheimerfeld 282,undefined
[8] D-69120 Heidelberg (Germany),undefined
[9] EMBL,undefined
[10] Meyerhofstrasse 1,undefined
[11] D-69117 Heidelberg (Germany),undefined
[12] Department of Molecular Biology,undefined
[13] University of Bergen,undefined
[14] Thormoehlensgt 55,undefined
[15] N-5020 Bergen (Norway),undefined
来源：
Cellular and Molecular Life Sciences CMLS | 1998年 / 54卷 / 1期
关键词：
Key words. Epigenetics; chromatin; transcription; silencing; acetylation; dosage compensation; methylation; paramutation.;
D O I：
10.1007/s000180050120
中图分类号：
学科分类号：
摘要：
Cis-acting binding sites for transcription activators cannot explain the patterned expression of genes during development, nor a large range of phenomena that result from gene transplacement. Heritable states of transcriptional regression or activation sequences are influenced not only by the chromosomal context of the promoter but also by modifications of histones and DNA, and long-range interactions between distant chromosomal elements. The molecular dissection of these epigenetic phenomena has become an exciting topic of reserch, revealing highly conserved mechanisms at work in chromatin-mediated gene control.
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页码：1 / 5
页数：4
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