pH-responsive polymeric micelles with tunable aggregation-induced emission and controllable drug release

被引：0
|
作者：
Yu Dai
Dengjin Wu
Shijun Lin
Xin Ma
Xiaojin Zhang
Fan Xia
机构：
[1] China University of Geosciences,Engineering Research Center of Nano
来源：
Journal of Nanoparticle Research | 2019年 / 21卷
关键词：
pH-responsive polymeric micelles; Hydrogen-bonding interaction; Aggregation-induced emission; Drug release; Self-assembly; Biomaterials; Nanomedicine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Stimuli-responsive polymeric micelles as a drug delivery vehicle have made important contributions to the development of controllable drug release. Here we develop pH-responsive polymeric micelles with tunable aggregation-induced emission and controllable drug release. Polymeric micelles in nano-sized spherical shape (about 140 nm) were mediated via hydrogen-bonding interaction between phenol groups of 4,4′-(1,2-diphenylethene-1,2-diyl)diphenol (TPE-2OH) and amine groups of poly(ethylene glycol)-block-linear polyethylenimine-block-poly(ε-caprolactone) (PEG-PEI-PCL). The results show that polymeric micelles are pH-responsive with turn-on fluorescence and sustained drug release inside cells, which has hope in simultaneously achieving cell imaging and cancer therapy.
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