Complement in ANCA-associated vasculitis: mechanisms and implications for management

被引：0
|
作者：
Min Chen
David R. W. Jayne
Ming-Hui Zhao
机构：
[1] Peking University First Hospital,Renal Division, Department of Medicine
[2] Institute of Nephrology,Department of Medicine
[3] Peking University,undefined
[4] Key Laboratory of Renal Disease,undefined
[5] Ministry of Health of China,undefined
[6] Addenbrooke's Hospital,undefined
来源：
Nature Reviews Nephrology | 2017年 / 13卷
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学科分类号：
摘要：
Activation of the complement system through the alternative pathway is necessary for the development of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in animal modelsC5a has a key role in AAV, linking inflammation and the coagulation systemNeutrophils, ANCA and the complement system form a positive feedback loop in the development of AAVInhibition of the complement system, particularly by targeting C5a, is a potential therapeutic approach for AAV
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页码：359 / 367
页数：8
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