We discuss flavor-violating constraints and consequently possible charged Higgs boson phenomenology emerging from a four-zero Yukawa texture embedded within the Type-III 2-Higgs Doublet Model (2HDM-III). Firstly, we show in detail how we can obtain several kinds of 2HDMs when some parameters in the Yukawa texture are absent. Secondly, we present a comprehensive study of the main B-physics constraints on such parameters induced by flavor-changing processes, in particular on the off-diagonal terms of such a texture: i.e., from μ − e universality in τ decays, several leptonic B-decays (B → τ ν, D →μν and Ds →lν), the semi-leptonic transition B →Dτν, plus B →Xsγ, including B0− \documentclass[12pt]{minimal}
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\begin{document}$ \overline{B} $\end{document}0 mixing, Bs → μ+μ− and the radiative decay Z → b\documentclass[12pt]{minimal}
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\begin{document}$ \overline{b} $\end{document}. Thirdly, having selected the surviving 2HDM-III parameter space, we show that the H−c\documentclass[12pt]{minimal}
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\begin{document}$ \overline{b} $\end{document} coupling can be very large over sizable expanses of it, in fact, a very different situation with respect to 2HDMs with a flavor discrete symmetry (i.e., \documentclass[12pt]{minimal}
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\begin{document}$ \mathcal{Z} $\end{document}2) and very similar to the case of the Aligned-2HDM (A2HDM) as well as of models with three or more Higgs doublets. Fourthly, we study in detail the ensuing H± phenomenology at the Large Hadron Collider (LHC), chiefly the c\documentclass[12pt]{minimal}
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\begin{document}$ \overline{b} $\end{document} → H+ production mode and the H+ → c\documentclass[12pt]{minimal}
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\begin{document}$ \overline{b} $\end{document} decay channel while assuming τ+ντ decays in the former and t → bH+ production in the latter, showing that significant scope exists in both cases.