Functions of astrocytes and their potential as therapeutic targets

被引:1
|
作者
Harold K. Kimelberg
Maiken Nedergaard
机构
[1] Ordway Research Institute,Center for Translational Neuromedicine, Department of Neurosurgery
[2] University of Prochester Medical School,undefined
来源
Neurotherapeutics | 2010年 / 7卷
关键词
Astrocytes; potassium buffering; pH control; receptors; transmitter uptake; blood flow; aquaporins; lactate shuttle; antioxidant; Müller cells; ensheathment;
D O I
暂无
中图分类号
学科分类号
摘要
Astrocytes are often referred to, and historically have been regarded as, support cells of the mammalian CNS. Work over the last decade suggests otherwise—that astrocytes may in fact play a more active role in higher neural processing than previously recognized. Because astrocytes can potentially serve as novel therapeutic targets, it is critical to understand how astrocytes execute their diverse supportive tasks while maintaining neuronal health. To that end, this review focuses on the supportive roles of astrocytes, a line of study relevant to essentially all acute and chronic neurological diseases, and critically re-evaluates our concepts of the functional properties of astrocytes and relates these functions and properties to the intricate morphology of these cells.
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页码:338 / 353
页数:15
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