Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp.

被引：0
|
作者：
Bora Mun
Weihong Wang
Hiyoung Kim
Dongyup Hahn
Inho Yang
Dong Hwan Won
Eun-hee Kim
Jihye Lee
Chulkyeong Han
Hyunji Kim
Merrick Ekins
Sang-Jip Nam
Hyukjae Choi
Heonjoong Kang
机构：
[1] Seoul National University,Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences
[2] Queensland Museum,Department of Chemistry and Nano Science
[3] Ewha Womans University,College of Pharmacy
[4] Yeungnam University,Research Institute of Oceanography
[5] Seoul National University,undefined
来源：
Archives of Pharmacal Research | 2015年 / 38卷
关键词：
5α,8α-epidioxy sterol; sp.; Cytotoxicity; Pancreatic cancer; Renal cancer; Colorectal cancer;
D O I：
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中图分类号：
学科分类号：
摘要：
Three new sterols, 5α,8α-epidioxy-24-norcholesta-6,9(11),22-trien-3β-ol (1), 5α,8α-epidioxy-cholesta-6,9(11),24-trien-3β-ol (2), and 5α,8α-epidioxy-cholesta-6,23-dien-3β,25-diol (3), with four known sterols (4–7) were isolated from a marine sponge Monanchora sp. Their chemical structures were elucidated by extensive spectroscopic analysis. Compounds 1 and 3–7 showed moderate cytotoxicity against several human carcinoma cell lines including renal (A-498), pancreatic (PANC-1 and MIA PaCa-2), and colorectal (HCT 116) cancer cell lines.
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页码：18 / 25
页数：7
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