Effect of focal cerebral ischemia on nitric oxide synthase expression in rats

被引：4
|
作者：
Homma H. [1 ]
Mizushima H. [1 ]
Arai Y. [1 ]
Dohi K. [1 ]
Matsumoto K. [1 ]
Shioda S. [2 ]
Nakai Y. [2 ]
机构：
[1] Department of Neurosurgery, Showa University, School of Medicine, Shinagawa-ku, Tokyo 142
[2] Department of Anatomy, Showa University, School of Medicine, Tokyo
来源：
Medical Electron Microscopy | 1997年 / 30卷 / 2期
关键词：
Cerebral ischemia; Immunohistochemistry; Nitric oxide; Nitric oxide synthase; Rat;
D O I：
10.1007/BF01545082
中图分类号：
学科分类号：
摘要：
Time- and cell-type-dependent immunohistochemical activity of nitric oxide synthase (NOS) was investigated in rat cerebral cortex following focal ischemia and the local concentration of nitric oxide (NO) was measured. NO concentration increased 2 min after the ischemia. Brain NOS-immunoreactive neurons increased in number 5 min after the ischemia. Endothelial cell NOS immunoreactivity was first detected in vascular endothelial cells and astrocytes 5 min after the ischemia, and it increased again during 60 min to 4 days after the ischemia in reactive astrocytes. Inducible NOS immunoreactivity was detected in astrocytes, vascular endothelium, and microglia/macrophages at the periphery of the ischemic core during 2-4 days after the ischemia. © The Clinical Electron Microscopy Society of Japan 1997.
引用
收藏
页码：55 / 62
页数：7
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