RNF12 initiates X-chromosome inactivation by targeting REX1 for degradation

被引：0
|
作者：
Cristina Gontan
Eskeatnaf Mulugeta Achame
Jeroen Demmers
Tahsin Stefan Barakat
Eveline Rentmeester
Wilfred van IJcken
J. Anton Grootegoed
Joost Gribnau
机构：
[1] Erasmus MC,Department of Reproduction and Development
[2] University Medical Center,Biomics Department
[3] Dr Molewaterplein 50,undefined
[4] 3015 GE Rotterdam,undefined
[5] The Netherlands,undefined
[6] Proteomics Center,undefined
[7] Erasmus MC,undefined
[8] University Medical Center,undefined
[9] Dr Molewaterplein 50,undefined
[10] 3015 GE Rotterdam,undefined
[11] The Netherlands ,undefined
[12] Erasmus MC,undefined
[13] University Medical Center,undefined
[14] Dr Molewaterplein 50,undefined
[15] 3015 GE Rotterdam,undefined
[16] The Netherlands,undefined
来源：
Nature | 2012年 / 485卷
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学科分类号：
摘要：
The pluripotency factor REX1 is a key target of RNF12 during X-chromosome inactivation; degradation of REX1 by RNF12 leads to relief of its inhibitory action on X-chromosome inactivation.
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页码：386 / 390
页数：4
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