Mitosis as an anti-cancer drug target

被引：0
|
作者：
Anna-Leena Salmela
Marko J. Kallio
机构：
[1] VTT Technical Research Centre of Finland,VTT Biotechnology for Health and Wellbeing
来源：
Chromosoma | 2013年 / 122卷
关键词：
Anti-mitotics; LMW inhibitors; Mitosis; Cancer; Drug development;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Suppression of cell proliferation by targeting mitosis is one potential cancer intervention. A number of existing chemotherapy drugs disrupt mitosis by targeting microtubule dynamics. While efficacious, these drugs have limitations, i.e. neuropathy, unpredictability and development of resistance. In order to overcome these issues, a great deal of effort has been spent exploring novel mitotic targets including Polo-like kinase 1, Aurora kinases, Mps1, Cenp-E and KSP/Eg5. Here we summarize the latest developments in the discovery and clinical evaluation of new mitotic drug targets.
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页码：431 / 449
页数：18
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